Restylane® (Hyaluronic Acid Filler)

What is Restylane dermal filler?

U.S. Food and Drug Administration (FDA)-approved Restylane® injectable gel is a cosmetic “filler” that contains hyaluronic acid (HA), a natural substance that is found in the body. HA gives volume and elasticity to the skin, but as the body ages, HA levels decrease, resulting in loose skin and wrinkling. When injected, Restylane gel is designed to plump the skin beneath lines and wrinkles, smoothing them out and making them less noticeable.

Julie Holesh, PA

Physician assistant Julie Holesh is board-certified by the National Commission on Certification of Physician Assistants. With both an artistic eye and medical expertise, she can help you achieve optimal skin quality with injectables, laser treatments, and other med spa services.

Julie Holesh, PA-C

Common areas treated with Restylane

The most common areas for Restylane treatment are the glabellar lines (which run between the eyebrows) and the nasolabial folds (which run from the sides of the nose to the corners of the mouth). Restylane injectable gel is also FDA-approved, for those 21 and older, for enhancing the lips. According to manufacturer Galderma, results can last from 6 months to one year, at which point the hyaluronic acid is reabsorbed by the body.

  • Treats volume loss
  • Fills lines, creases, and wrinkles
  • Enhances features like the lips and cheeks
  • Immediate effects

Dermal Fillers: Substances designed to be injected beneath the skin surface to add volume and fullness.

Hyaluronic Acid (HA): A natural substance in the skin that helps the skin retain moisture and softness, and adds volume.

Nasolabial Folds: The deep wrinkles or lines that run from the side of the nose to the corner of the mouth.

Perlane: The original name for Restylane Lyft, a type of Restylane used to treat moderate to severe facial folds; it is denser and used for deeper injection.

Lidocaine: An anesthetic often mixed with Restylane to minimize pain during the injection process.

Cannula: A thin tube used to administer the Restylane dermal filler.

Botox: Another type of cosmetic injectable that might be used in conjunction with Restylane.

Volume Loss: The decrease in facial fat and collagen as one ages, often addressed by dermal fillers.

Facial Rejuvenation: The process of restoring a youthful appearance to the face, often through the use of dermal fillers and other cosmetic procedures.

Contraindication: Conditions or factors that serve as reasons to withhold a certain medical treatment due to the harm that it would cause the patient.

Granuloma: A mass of tissue that can form when the body tries to wall off substances it perceives as foreign but cannot eliminate.

Bruising and Swelling: Common side effects of dermal fillers.

Touch-Up Treatment: An additional treatment that might be necessary to maintain the desired effect of dermal fillers.

Collagen: A protein in the skin and other connective tissues that provides structure and elasticity.

Biocompatible: The quality of not having toxic or injurious effects on biological systems.

Delayed Onset Nodules (DONs): Lumps or bumps that appear weeks to months after filler injection.

Restylane Kysse

Restylane Kysse is specifically designed to provide flexible movement and natural-looking volume that is proven to last for up to 1 year. It effectively adds volume, smooths upper lip lines, and enhances lip color.

I went to Dr. Claytor for a lip augmentation in June 2016. Every aspect of the office visit was exceptional from the front office staff, to the procedure itself. Dr. Claytor is a physician who takes great pride in the patient experience, and the outcomes of your procedure. I’m a very hesitant patient when it comes to plastic surgery. I prefer results that look natural, and I want the least “down time” possible. Dr. Claytor checked in on my thoughts throughout the process to ensure I was comfortable with the amount of product used, and how Inwas feeling. I’ve had lip procesures before and have always looked bruised afterwards. With just a little bit of ice, and a carefully handed surgeon, I did not show a single bruise and my lips were more than ok to show in public immediately after. I was so pleased with my experience at Dr. Claytors office and I will definitely be back in the future. Thank Dr. Claytor- and Debbie Lander- for taking such great care of your patients!”


Restylane Defyne

Restylane Defyne unique formulation is clinically proven to reduce nasolabial folds and marionette lines, as well as treat mild-to-moderate chin retrusion that can worsen as we age. Restylane Defyne is specially designed to correct deep lines and wrinkles and improve chin projection while also allowing you the natural movement needed to perform everyday facial expressions.

Schedule your Restylane consultation today

Philadelphia board certified plastic surgeon Dr. Brannon Claytor and our highly-trained physician assistant Julie Holesh are passionate about helping patients reach their goals with non-surgical treatments like Restylane. To schedule a personal consultation, please call our Bryn Mawr office at 610.527.4833 or contact us online.

We proudly offer a full range of premium products, including BotoxXeominDAXXIFY, Dysport, and Kybella, as well as the dermal fillers Juvéderm, the RHA filler collectionBellafill and Sculptra Aesthetic.  We frequently serve patients from Philadelphia, Bryn Mawr, and the Main Line area (including Villanova, Ardmore, Radnor and Lower Merion).

References »

Wollina U, Goldman A. Facial vascular danger zones for filler injections. Dermatology and Therapy. 2020 Nov;33(6):e14285. doi: 10.1111/dth.14285. 

Trinh LN, Gupta A. Hyaluronic Acid Fillers for Midface Augmentation: A Systematic Review. Facial Plastic Surgery & Aesthetic Medicine. 2021 Oct;37(5):576-584. doi: 10.1055/s-0041-1724122. 

Cavallini M, Gazzola R, Metalla M, Vaienti L. The role of hyaluronidase in the treatment of complications from hyaluronic acid dermal fillers. Aesthetic Surgery Journal. 2013 Nov 1;33(8):1167-74. doi: 10.1177/1090820X13511970. 

Alcantara AR, Machado-Filho DA, Provenzano RG, Vieira LC, Kim JH, Cortes ARG. NonSurgical Approach to Treat Lip Vascular Complication Caused by Hyaluronic Acid Filler. Journal of Craniofacial Surgery. 2022 Jan-Feb 01;33(1):e76-e78. doi: 10.1097/SCS.0000000000008012. 

Marcus K, Moradi A, Kaufman-Janette J, Ablon G, Donofrio L, Chapas A, Kazin R, Rivkin A, Rohrich RJ, Weiss R, George R. A Randomized Trial to Assess Effectiveness and Safety of a Hyaluronic Acid Filler for Chin Augmentation and Correction of Chin Retrusion. Plastic and Reconstructive Surgery . 2022 Dec 1;150(6):1240e-1248e. doi: 10.1097/PRS.0000000000009733. 

Areas Served:

Portrait of Dr. Claytor smiling

Medically reviewed by Dr. R. Brannon Claytor — Updated on Feb 20, 2024